Unique Ultrastructural Alterations in the Placenta Associated With Macrosomia Induced by Gestational Diabetes Mellitus

作     者：Junxiang Wei Tianyu Dong Mingxia Chen Xiao Luo Yang Mi 

作者机构：Department of ObstetricsNorthwest Women’s and Children’s HospitalXi’an 710061China Laboratory of Electron MicroscopeHealth Science Center of Xi’an Jiaotong UniversityXi’an 710049China Department of Physiology and PathophysiologySchool of Basic Medical SciencesHealth Science Center of Xi’an Jiaotong UniversityXi’an 710049China 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2024年第6卷第3期

页      面：164-172页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the research grant from the Key Research and Development Program of Shaanxi Province(no.2022SF-125 2021ZDLSF02-14) 

主　　题：Placenta Macrosomia Gestational diabetes mellitus Ultrastructure Morphology 

摘      要：Objective:To investigate the morphological and ultrastructural alterations in placentas from pregnancies with gestational diabetes mellitus(GDM)–induced macrosomia,term nondiabetic macrosomia,and normal ***:Sixty full-term placentaswere collected,and clinical data alongwith informed consent were obtained from pregnant womenwho underwent regular visit checks and delivered their newborns in Northwest Women’s and Children’s Hospital between May and December *** were divided into three equal groups:normal pregnancy(control group),nondiabetic macrosomia group,and macrosomia complicated with GDM(diabetic macrosomia)*** morphological data of placentas were recorded,and placental samples were processed for examination of ultrastructural and stereological changes using transmission electron *** of variance and chi-squared test were used to examine the differences among the three groups for continuous and categorical variables,***:The baseline characteristics of mothers and neonates did not differ across the three groups,except for a significantly higher birth weight in the diabetic macrosomia group(4172.00±151.20 g vs.3192.00±328.70 g,P0.001)and nondiabetic macrosomia group(4138.00±115.20 g vs.3192.00±328.70 g,P0.001)comparedwith control *** of the placentas revealed that placental weight was also highest in the diabeticmacrosomia group comparedwith control group(810.00±15.81 g vs.490.00±51.48 g,P0.001)and nondiabetic macrosomia group(810.00±15.81 g vs.684.00±62.69 g,P0.001),but the ratio of neonatal birth weight to placental weight(BW/PW)was significantly lower in the diabetic macrosomia group compared with that in the control group(5.15±0.19 vs.6.54±0.63,P0.001)and nondiabetic macrosomia group(5.15±0.19 vs.6.09±0.52,P0.001)*** contrast,the BW/PW ratio in nondiabetic macrosomia did not differ significantly from that in the control *** ultrastructural changes in terminal v