Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach

作     者：Alexander E Sherman Yana Zavros 

作者机构：Department of Molecular and Cellular PhysiologyCollege of MedicineUniversity of CincinnatiCincinnatiOH 45267-0576United States 

出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第6期

页      面：103-108页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by American Cancer Society Research Scholar Award No.119072-RSG-10-167-01-MPC(to Zavros Y) 

主　　题：Helicobacter pylori Interleukin-1β Acid secretion Gastric tissue homeostasis 

摘      要：Despite advances in treatment and the declining incidence,gastric cancer remains the second leading cause of cancer-related deaths in the *** the progression from inflammation to cancer in the stomach is crucial in the development of novel therapies and strategies for treating this *** inflammation of the stomach is typically caused by Helicobacter pylori(***)and resulting lesions may lead to gastric *** the progression from inflammation to cancer,the stomach epithelium changes with evidence of the disruption of normal epithelial cell differentiation and infiltrating inflammatory *** with the development of atrophic gastritis and metaplasia,is the loss of the gastric morphogen Sonic Hedgehog(Shh).Given its critical role as a regulator of gastric tissue homeostasis,the disruption of Shh expression during inflammation correlates with the loss of normal epithelial cell differentiation,but this has only recently been rigorously tested in vivo using a unique mouse model of targeted gastric Shh *** pre-neoplastic lesions such as atrophic gastritis and in-testinal metaplasia are associated with the loss of Shh within the acid-secreting glands of the stomach,there is a clear link between elevated Shh and signaling to gastric *** current review focuses on the effects of aberrant Shh expression and its role in the development of gastric cancer,specifically in response to *** infection.