Ribosome Biogenesis Factor Bmsl-like Is Essential for Liver Development in Zebrafish

作     者：Yong Wanga,Yue Luoa,Yunhan Hong(b,),Jinrong Peng(a,),Lijan Lo(a,b,) a College of Animal Sciences,Zhejiang University,Hangzhou 310058,China b Department of Biological Sciences,National University of Singapore,Science Drive 4,Singapore 117543,Singapore 

作者机构：College of Animal Sciences Zhejiang University Hangzhou 310058 China Department of Biological Sciences National University of Singapore Science Drive 4 Singapore 117543 Singapore 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2012年第39卷第9期

页      面：451-462页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the grants from the National Natural Science Foundation of China(NSFC)(No.31171391) to LJL an NSFC grant(No. 30825025) to JRP and a grant from the National Research Foundation of Singapore(R-154-000-529-281) to YHH 

主　　题：Liver development Digestive organ development Ribosome biogenesis Bmsl like Zebrafish 

摘      要：Ribosome biogenesis in the nucleolus requires numerous nucleolar proteins and small non-coding *** them is ribosome biogenesis factor Bmsl,which is highly conserved from yeast to *** yeast,Bmsl initiates ribosome biogenesis through recruiting Rcll to ***,little is known about the biological function of Bmsl in *** we report that Bmsl plays an essential role in zebrafish liver *** identified a zebrafish bms1l^（sq163） mutant which carries a T to A mutation in the gene bmsl-like（bms1l）.This mutation results in L^（152） to Q^（152） substitution in a GTPase motif in ***,bmsll^（sq163） mutation confers hypoplasia specifically in the liver,exocrine pancreas and intestine after 3 days post-fertilization（dpf）.Consistent with the bmsll^（sq163） mutant phenotypes,whole-mount in situ hybridization（WISH） on wild type embryos showed that bmsll transcripts are abundant in the entire digestive tract and its accessory *** for phospho-Histone 3（P-H3） and TUNEL assay revealed that impairment of hepatoblast proliferation rather than cell apoptosis is one of the consequences of bms1l（sq163） giving rise to an under-developed ***,our findings demonstrate that Bmsll is necessary for zebrafish liver development.