Pharmacia and biological functionalities of nutrient broth dispersed multi-walled carbon nanotubes:A novel drug delivery system

作     者：Li, Di Xiao, Sai Jin Huang, Cheng Zhi 

作者机构：Key Laboratory on Luminescence and Real-Time Analysis Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 China College of Pharmaceutical Sciences Southwest University Chongqing 400715 China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2010年第53卷第3期

页      面：611-617页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：support from the National Natural Science Foundation of China (Grant No 206775065) Ministry of Education of China (Grant No 20060635003) 

主　　题：drug delivery system multiwalled carbon nanotubes biocompatibility pharmacodynamic effect flow cytometry 

摘      要：A new drug delivery system was developed using the interaction of nutrient broth treated multi-walled carbon nanotubes(NBT-MWCNTs) and cefotaxime sodium(CTX) as a *** factors of the drug delivery system include dispersion effect,biocompatibility of NBT-MWCNTs,pharmacodynamic effect and delivery efficiency in *** was found that MWCNTs can be well dispersed in the nutrient broth and stable at least for one week at 4 °*** formed NBT-MWCNTs suspension scarcely exhibits toxicity to *** at concentrations lower than 10.24 μg/mL,but displays enhanced pharmacodynamic effect of CTX via its bridge effect and targeted *** with general acid treated MWCNTs(AT-MWCNTs),our present NBT-MWCNTs show good biocompatibility,enhanced pharmacodynamic effect,and high delivery efficiency.