Recent and currently emerging medical treatment options for the treatment of alcoholic hepatitis

作     者：Gabriel L Reep Roger D Soloway 

作者机构：Department of Internal medicineUniversity of Texas Medical Branch Division of Gastroenterology and HepatologyDepartment of Internal MedicineUniversity of Texas Medical Branch 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2011年第3卷第8期

页      面：211-214页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Alcoholic hepatitis Tumor necrosis factor-α inhibitors Infliximab Etanercept Antioxidants Probiotics Rifaximin Betaine Granulocytapheresis 

摘      要：Patients with severe alcoholic hepatitis (AH) need to be treated with specific treatment for better *** available specific treatment modalities are use of corticosteroids or ***,the response rate to these drugs is only about 50%-60%.Hence,there is an urgent need for better and more effective treatment *** necrosis factor plays an important role in the pathogenesis of ***,agents blocking the action of tumor necrosis factor have not been found to be *** the randomized studies evaluating these agents showed an adverse effect and more infections in treated *** role of tumor necrosis factor in hepatic regen-eration explaining this contrast is *** stress and inflammation derived from gut bacteria ate two main components in the pathogenesis of AH laying foundation for the role of antioxidants,probiotics,and antibiotics in the management of *** article reviews the current data and status of these newer agents for the treatment of *** the various options available,Vitamin E and N-acetylcysteine (NAC) have shown great promise for clinical use as adjunct to *** these encouraging data,future well designed studies are suggested to assess Vitamin E and NAC before their routine use in clinical practice in the management of AH.