A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis:Antibacterial,hemostasis,immune reprogramming,pro-osteo-/angiogenesis and recruitment

作     者：Shiyuan Yang Yan Zhu Chunxiao Ji Huimin Zhu An Lao Ran Zhao Yue Hu Yuning Zhou Jia Zhou Kaili Lin Yuanjin Xu 

作者机构：Department of Oral SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghaiChina Department of Oral and Cranio-maxillofacial SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Oral Mucosal DiseasesShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第41卷第11期

页      面：239-256页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Natural Science Foundation of China(82370921,82071082) Program of Shanghai Technology Research Leader(23XD1430800) Fund of Department of Oral and Maxillofacial Surgery(Department 2023-01) 

主　　题：Hydrogel Periodontitis Alveolar bone regeneration Quercetin ZIF-8 

摘      要：Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues,resulting in tooth *** eradication of pathogenic microorganisms,persistent malignant inflammation and impaired osteo-/angiogenesis are currently the primary challenges to control disease progression and rebuild damaged alveolar ***,existing treatments for periodontitis fail to comprehensively address these ***,an injectable composite hydrogel(SFD/CS/ZIF-8@QCT)encapsulating quercetin-modified zeolitic imidazolate framework-8(ZIF-8@QCT)is *** hydrogel possesses thermo-sensitive and adhesive properties,which can provide excellent flowability and post-injection stability,resist oral fluid washout as well as achieve effective tissue ***,it is observed that SFD/CS/ZIF-8@QCT exhibits a rapid localized hemostatic effect following implantation,and then by virtue of the sustained release of zinc ions and quercetin exerts excellent collective functions including antibacterial,immunomodulation,pro-osteo-/angiogenesis and pro-recruitment,ultimately facilitating excellent alveolar bone ***,our study also demonstrates that the inhibition of osteo-/angiogenesis of PDLSCs under the periodontitis is due to the strong inhibition of energy metabolism as well as the powerful activation of oxidative stress and autophagy,whereas the synergistic effects of quercetin and zinc ions released by SFD/CS/ZIF-8@QCT are effective in reversing these biological ***,our study presents innovative insights into the advancement of biomaterials to regenerate alveolar bone in periodontitis.