Clinical characteristics of human infection with a novel avian-origin influenza A（H10N8） virus

作     者：Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng 

作者机构：Nanchang University First Affiliated Hospital Nanchang Jiangxi 330006 China Nanchang First Hospital Nanchang Jiangxi 330008 China Jiangxi Province Center for Disease Control and PreventionNanchang Jiangxi 330038 China Jiangxi Provincial People's Hospital Nanchang Jiangxi 330006China Nanchang University Fourth Affiliated Hospital Nanchang Jiangxi 330003 China Chinese Center for Disease Control and Prevention Beijing 102206China Department of Respiratory and Critical Care Medicine PekingUniversity People's Hospital Beijing 100044 China Oxford University Clinical Research Unit -Wellcome Trust MajorOverseas Programme Hanoi Viemam 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第18期

页      面：3238-3242页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the grants from Special Fund for Health Scientific Research in the Public Interest Program from National Health and Family Planning Commission of China National 12th Five-Year Plan Major Scientific and Technological Program from Ministry of Science and Technology of China Investigation of Clinical Characteristics and Management on Human Cases Infected with H7N9 from Ministry of Science and Technology of China 

主　　题：human infection avian influenza A(H10N8) virus reassortment clinical characteristics 

摘      要：Background Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A （H10N8） virus which can infect humans and cause severe diseases. Methods Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A （H10N8） virus in Nanchang, Jiangxi Province, China. Results Three cases of human infection with a new reassortment avian influenza A（H10N8） virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome （ARDS） and intractable respiratory failure. Conclusion This novel reassortment avian influenza A （H10N8） virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.