CCDC181 is required for proper spermiogenesis in mice

作     者：Xirui Zi Qingchao Li Yue Lu Qian Lyu Heng Guo Xiaoqian Meng Jun Zhou Huijie Zhao 

作者机构：Center for Cell Structure and FunctionShandong Provincial Key Laboratory of Animal Resistance BiologyCollaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinanShandong 250014China State Key Laboratory of Medicinal Chemical BiologyHaihe Laboratory of Cell EcosystemCollege of Life SciencesNankai UniversityTianjin 300071China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2024年第51卷第11期

页      面：1327-1330页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by National Natural Science Foundation of China(32270807 and 31900538) Shandong Natural Science Foundation(2022HWYQ-075 and tsqn202211109) 

主　　题：outer arrangement fibers 

摘      要：Cilia are hair-like cellular projections essential for development and homeostasis,which can be grouped into either immotile or motile cilia based on their *** vertebrates,motile cilia that line the brain ventricles,respiratory tracts,and reproductive tracts exist as multiple cilia and beat in a coordinated fashion to generate a directional fluid flow across the epithelial surfaces(Lyu et al.,2024).In contrast,sperm cells have a single flagellum that shares a similar axoneme arrangement but possesses unique accessory structures,including the mitochondrial sheath,the fibrous sheath,and the outer dense fibers(Linck et al.,2016).Some ciliary proteins display distinct cellular distributions in multiple motile cilia and sperm *** instance,outer dense fiber protein 2(ODF2)associates with basal bodies in tracheal motile cilia but is abundant in sperm flagella(Zhao et al.,2021;Zhu et al.,2022).These differences potentially grant sperm flagella distinctive properties.