Potential clinical application of microRNAs in bladder cancer

作     者：Pei Wang Xiaowei Wei Xiaojun Qu Yefei Zhu 

作者机构：Laboratory Medicine Centerthe Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China 

出 版 物：《Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2024年第38卷第4期

页      面：289-306页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the China Postdoctoral Science Foundation(Grant No.2022M721404) the Natural Science Foundation of Jiangsu Province(Grant No.BK20220737) the Social Development Foundation of Clinical Frontier Technology of Jiangsu Province(Grant No.BE2017763) the Medical Research Project of Jiangsu Province Health Committee(Grant No.K2019020) 

主　　题：bladder cancer microRNAs biomarker diagnosis detection method 

摘      要：Bladder cancer(BC)is the tenth most prevalent malignancy globally,presenting significant clinical and societal challenges because of its high incidence,rapid progression,and frequent ***,cystoscopy and urine cytology serve as the established diagnostic methods for ***,their efficacy is limited by their invasive nature and low ***,the development of highly specific biomarkers and effective noninvasive detection strategies is imperative for achieving a precise and timely diagnosis of BC,as well as for facilitating an optimal tumor treatment and an improved ***(miRNAs),short noncoding RNA molecules spanning around 20–25 nucleotides,are implicated in the regulation of diverse carcinogenic *** altered miRNAs form robust functional regulatory networks that exert a notable influence on the tumorigenesis and progression of *** into aberrant miRNAs derived from blood,urine,or extracellular vesicles indicate their potential roles as diagnostic biomarkers and prognostic indicators in BC,enabling miRNAs to monitor the progression and predict the recurrence of the ***,the investigation centered on miRNA as a potential therapeutic agent presents a novel approach for the treatment of *** review comprehensively analyzes biological roles of miRNAs in tumorigenesis and progression,and systematically summarizes their potential as diagnostic and prognostic biomarkers,as well as therapeutic targets for ***,we evaluate the progress made in laboratory techniques within this field and discuss the prospects.