Telitacicept as a novel treatment for refractory lupus nephritis complicated by podocytic infolding glomerulopathy

作     者：Lu Zhou Haoguang Li Rongwei Zhang Qifeng Jiang Xinwang Duan Lu Zhou;Haoguang Li;Rongwei Zhang;Qifeng Jiang;Xinwang Duan

作者机构：Department of Rheumatology and ImmunologyThe Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangChina Department of PathologyGuangzhou Huayin Medical Laboratory CenterGuangzhouChina 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2024年第4卷第3期

页      面：186-188页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：National Key Research and Development Program of China(2021YFC2501304) Science and Technology Program of Department of Health of Jiangxi Province(20204254) Key Research and Development Program of Jiangxi Municipal Science and Technology Department(20192BBGL70024) 

主　　题：nephritis lupus Lupus 

摘      要：To the Editor,Lupus nephritis(LN),a renal symptom of systemic lupus erythematosus(SLE),frequently causes severe organ damage in SLE patients.1 There is no consensus on the definition of refractory LN,which has been suggested to occur when remission is not achieved after 3–12 months of combined glucocorticoids and immunosuppressive therapy.2 Podocytic infolding glomerulopathy(PIG),a rare type of glomerular morphological alteration,is primarily characterized by the presence of microspheres,microtubular structures,or a combination of the two,which are associated with podocyte infolding into the glomerular basement membrane(GBM).3,4 The exact pathogenesis of PIG remains unclear,but it may be associated with autoimmune diseases like SLE and Sjögren s *** occurrence of refractory LN complicated by PIG is rare and poses significant challenges in ***,we endeavor to provide the patient with benefits by employing a novel treatment,Telitacicept,which has demonstrated the potential to achieve complete renal remission in such cases.