Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity

作     者：Cijun Shuai Xiaoxin Shi Kai Wang Yulong Gu Feng Yang Pei Feng Cijun Shuai;Xiaoxin Shi;Kai Wang;Yulong Gu;Feng Yang;Pei Feng

作者机构：State Key Laboratory of Precision Manufacturing for Extreme Service PerformanceCollege of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Institute of Additive ManufacturingJiangxi University of Science and TechnologyNanchang 330013China College of Mechanical EngineeringXinjiang UniversityUrumqi 830017China 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2024年第7卷第2期

页      面：105-120页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Natural Science Foundation of China(Nos.52275393 and 51935014) Hunan Provincial Natural Science Foundation of China(Nos.2021JJ20061,2020JJ3047,and 2019JJ50588) Jiangxi Provincial Natural Science Foundation of China(No.20224ACB204013) the Project of State Key Laboratory of High Performance Complex Manufacturing Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020(No.PT2020E002) Guangdong Province Precision Manufacturing and Intelligent Production Education Integration Innovation Platform(No.2022CJPT019) Independent Exploration and Innovation Project of Central South University(No.1053320220553) 

主　　题：Ag-doped Carbon nanotube/hydroxyapatite(CNT/HAP) Antibacterial properties Bone scaffold 

摘      要：Bacterial infection is a major problem following bone implant ***,poly-l-lactic acid/carbon nanotube/hydroxyapatite(PLLA/CNT/HAP)bone scaffolds possess enhanced mechanical properties and show good ***,wesynthesizedsilver(Ag)-dopedCNT/HAP(CNT/Ag-HAP)nanohybrids via the partial replacing of calcium ions(Ca2+)in the HAP lattice with silver ions(Ag+)using an ion doping technique under hydrothermal ***fically,the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT,and involved the partial replacement of Ca2+in the HAP lattice by doped Ag+as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal *** result-ing CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion(PBF-LB)to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial *** then found that Ag+,which pos-sesses broad-spectrum antibacterial activity,endowed PLLA/CNT/Ag-HAP scaffolds with this activity,with an antibacterial effectiveness of 92.65%.This antibacterial effect is due to the powerful effect of Ag+against bacterial structure and genetic material,as well as the physical destruction of bacterial structures due to the sharp edge structure of *** addition,the scaffold possessed enhanced mechanical properties,showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa,***,the scaffold also exhibited good bioactivity and cytocompatibility,including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells(MG63 cells).