Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies
作者机构：Key Laboratory for Molecular Diagnosis and Treatment of Hematologic DiseasesSecond Hospital of Shanxi Medical University Editorial OfficeFirst Hospital of Shanxi Medical University School of NursingShanxi Medical University
出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志(英文版))
年 卷 期：2024年第44卷第3期
页 面：417-426页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Fundamental Research Program of Shanxi Province:to Explore the Material Basis and Mechanism of Codonopsis Pilosula for Preventing and Treating Immune Thrombocytopenia based on Network Pharmacology and Molecular Docking (202203021221251) the Doctor Starting Foundation of First Hospital of Shanxi Medical University:Material Basis and Mechanism of Codonopsis Pilosula for Preventing and Treating Immune Thrombocytopenia (YB2203)
主 题：Meta-analysis alkaloids autoimmune diseases flavones saponins system evaluation
摘 要：OBJECTIVE: To investigate the efficacy of substances containing 3 types of active ingredients-saponins,flavones, and alkaloids on experimental animals with autoimmune diseases(AIDs).METHODS: The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO(CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, Pub Med,Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases;consequently, corresponding data extraction tables were prepared. Systematic Review Centre for Laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum ***: A total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin(IL)-1β[standardized mean difference(SMD) =-1.94, 95%confidence interval(CI)(-2.99,-0.90), P = 0.0003], IL-6 [SMD =-1.65, 95% CI(-2.33,-0.97,) P 0.000 01],IL-17 [SMD =-2.41, 95% CI(-3.61,-1.20), P 0.0001], tumor necrosis factor(TNF)-α [SMD =-1.84, 95%CI(-2.61,-1.06), P 0.0001], and interferon(IFN)-γ[SMD =-1.54, 95% CI(-2.43,-0.65), P = 0.0007], but increased serum levels of IL-4 [SMD = 1.30, 95% CI(0.15,2.44), P = 0.03) and IL-10 [SMD = 2.05, 95% CI(1.39,2.70), P 0.000 01) in animal models. However, no significant regulatory effect of these three active components was observed on serum levels of IL-2 [SMD =-0.63, 95% CI(-1.82, 0.57), P = 0.30].CONCLUTIONS: Substances containing saponins,flavones, and alkaloids regulated the changes of immunerelated cytokines, it may be a novel dietary substance to relieve and control autoimmune diseases in the future.
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