Tetrahedral framework nucleic acids/hyaluronic acidmethacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing

作     者：Cai Qi Qiang Sun Dexuan Xiao Mei Zhang Shaojingya Gao Bin Guo Yunfeng Lin Cai Qi;Qiang Sun;Dexuan Xiao;Mei Zhang;Shaojingya Gao;Bin Guo;Yunfeng Lin

作者机构：State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of StomatologySichuan UniversityChengduChina Sichuan Provincial Engineering Research Center of Oral BiomaterialsChengduChina Department of StomatologyThe First Medical CentreChinese PLA General HospitalBeijingChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2024年第16卷第3期

页      面：436-447页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by National Key R&D Program of China(2019YFA0110600) National Natural Science Foundation of China(82370929,81970916) Sichuan Science and Technology Program(2022NSFSC0002) Sichuan Province Youth Science and Technology Innovation Team(2022JDTD0021) Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD03202302) 

主　　题：properties. hydrogel anhydride 

摘      要：Bacterial resistance and excessive inflammation are common issues that hinder wound *** peptides(AMPs)offer a promising and versatile antibacterial option compared to traditional antibiotics,with additional anti-inflammatory ***,the applications of AMPs are limited by their antimicrobial effects and stability against bacterial *** are regarded as a promising drug delivery platform that could enhance the antibacterial properties and stability of ***,in this study,a composite hydrogel(HAMA/t-GL13K)was prepared via the photocross-linking method,in which tFNAs carry *** hydrogel was injectable,biocompatible,and could be instantly *** exhibited broad-spectrum antibacterial and anti-inflammatory properties by inhibiting the expression of inflammatory factors and scavenging ***,the hydrogel inhibited bacterial infection,shortened the wound healing time of skin defects in infected skin full-thickness defect wound models and reduced *** constructed HAMA/tFNA-AMPs hydrogels exhibit the potential for clinical use in treating microbial infections and promoting wound healing.