DNA condensation and size effects of DNA condensation agent

作     者：Yan-Hui Liu Chong-Ming Jiang Xin-Miao Guo Yan-Lin Tang Lin Hu 

作者机构：College of Science Guizhou University Guiyang 550025 China State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China Department of Physics Sun Yat-Sen University Guangzhou 510275 China 

出 版 物：《Frontiers of physics》 (物理学前沿（英文版）)

年 卷 期：2013年第8卷第4期

页      面：467-471页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 080402[工学-测试计量技术及仪器] 0838[工学-公安技术] 

基　　金：Key Laboratory of Biorheological Science and Technology of Ministry of Education National Natural Science Foundation of China, NSFC, (11047022, 11204045, SY20123089, SZ20113069) Ministry of Education of the People's Republic of China, MOE, (2012152) Chongqing University, CQU 

主　　题：DNA condensation Monte Carlo simulation size effects of condensation agent 

摘      要：Based on the model of the strong correlation of counterions condensed on DNA molecule, by tailoring interaction potential, interduplex spacing and correlation spacing between condensed counterions on DNA molecule and interduplex spacing fluctuation strength, toroidal configuration, rod-like configuration and two-hole configurations are possible. The size effects of counterion structure on the toroidal structure can be detected by this model. The autocorrelation function of the tangent vectors is found as an effective way to detect the structure of toroidal conformations and the generic pathway of the process of DNA condensation. The generic pathway of all of the configurations involves an initial nucleation loop, and the next part of the DNA chain is folded on the top of the initial nucleation loop with different manners, in agreement with the recent experimental results.