Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease

作     者：Sergio Rutella Franco Locatelli 

作者机构：Department of Pediatric Hematology/OncologyIRCCS Children's Hospital"Bambino Gesù"00165 RomeItaly Catholic University Medical School00168 RomeItaly Franco LocatelliUniversity of Pavia27100 PaviaItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第33期

页      面：3761-3775页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The "Stem Cell Project" Fondazione Roma Italy and by the Associazione Italiana per la Ricerca sul Cancro Milan Italy(AIRC Grant No.8556) 

主　　题：Dendritic cell Tolerance Gut Inflammatory bowel disease Cytokine Regulatory T cells 

摘      要：The gastrointestinal tract harbors a large number and diverse array of commensal bacteria and is an important entry site for *** these reasons,the intestinal immune system is uniquely dedicated to protect against infections,while avoiding the development of destructive inflammatory responses to the *** models have been proposed to explain how the immune system discriminates between,and appropriately responds to,commensal and pathogenic *** cells(DCs)and regulatory T cells(Treg)are instrumental in maintaining immune homeostasis and tolerance in the *** are virtually omnipresent and are remarkably plastic,having the ability to adapt to the influences of the *** DC populations with partially overlapping phenotypic and functional properties have been described in different anatomical *** in the draining mesenteric lymph nodes,in the intestinal lamina propria and in Peyer s patches partake both in the control of intestinal inflammation and in the maintenance of gut *** this respect,gutresident DCs and macrophages exert tolerogenic functions as they regularly encounter and sense commensal *** contrast,migrating DC subsets that are recruited to the gut as a result of pathogenic insults initiate immune ***,tolerogenic DCs act by promoting the differentiation and expansion of Treg cells that efficiently modulate gut inflammation,as shown both in preclinical models of colitis and in patients with inflammatory bowel disease(IBD).This article reviews the phenotypic and functional features of gut DC subsets and discusses the current evidence underpinning the DC contribution to the pathogenesis of the major clinical subtypes of human *** also addresses the potential clinical benefit derived from DC targeting either in vivo or in vitro.