Pre-Clinical Experimental Studies of Indomethacin-Releasing Copper Intrauterine Device

作     者：曹路敏 周玉玲 刘子龙 杜庆玲 李万 胡燕群 李玮 CAO Lumin,ZHOU Yuling,LIU Zilong,DU Qingling, LI Wan,HU Yanqun,LI Wei Family Planning Research Institute, Tongji Medical University, Wuhan 430030

作者机构：Family Planning Research Institute Tongji Medical University Wuhan 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2000年第20卷第3期

页      面：249-252页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100404[医学-儿少卫生与妇幼保健学] 10[医学] 

基　　金：This project was supported by a grant from Hubei Science and Technology Com mittee(No.96 1P190 1) 

主　　题：copper intrauterine device indomethacin prostaglandins endothelin endometrium copper ion 

摘      要：Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu 2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin releasing copper IUD (FICu IUD) on the PGI 2 was stronger than that on the TXA 2, the ratio of 6 keto PGF 1α /TXB 2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu IUD, and promote copper ion release. It was suggested that indomethacin released by FICu IUD could effectively reduce abnormal uterine bleeding.