Visualization of nasal powder distribution using biomimetic human nasal cavity model

作     者：Jiawen Su Yan Liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang Zeru Li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu Lixin Sun Jiwen Zhang Zhigang Wang Rui Yang Li Wu 

作者机构：Key Laboratory of Modern Preparation of TCMMinistry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug EvaluationSchool of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China Nantong Haimen People’s HospitalNantong 226199China Yangtze Delta Drug Advanced Research InstituteNantong 226126China Shenyang Pharmaceutical UniversityShenyang 110016China National Institutes for Food and Drug ControlBeijing 100000China Nanjing University of Chinese MedicineNanjing 210023China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第1期

页      面：392-404页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This research was funded by the Key Program for International Science and Technology Cooperation Projects of China(No.2020YFE0201700) the Innovation Leading Talents Short-term Program of Jiangxi Province,China(No.1262000102) Shanghai Science and Technology Plan(No.21DZ2260400,China) 

主　　题：Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution 

摘      要：Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal ***,no reliable method is currently available to assess its impact on delivery *** this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal *** results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and *** nasal cavity model was modified with dimethicone and validated to be suitable for the deposition *** experimental device produced the most satisfactory results with five spray ***,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,***,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo *** conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.