Impact of miRNAs on cardiovascular aging
Impact of miRNAs on cardiovascular aging作者机构：Institute for Bio-Medical Convergence College of Medicine Catholic Kwandong University Gangneung-sL Gangwon-do South Korea Catholic Kwandong University International St. Mary's Hospital Incheon Metropolitan City South Korea Department of Healthcare Management College of Medicine Catholic Kwandong University Gangneung-si Gangwond-do South Korea Department of Cardiovascular & Thoracic Surgery College of Medicine Catholic Kwandong University Gangneung-si Gangwond-do South Korea
出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)
年 卷 期：2015年第12卷第5期
页 面：569-574页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
基 金：supported by a Korea Science and Engineering Foundation grant funded by the Korean government (MEST) the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea
主 题：Aging heart Cardiovascular aging miRNA Senescence Vascular aging
摘 要：Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs （miRNAs） have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
维普期刊数据库