Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

作     者：Pengfei Zhao Yating Wang Xiao Yu Yabing Nan Shi Liu Bin Li Zhumei Cui Zhihua Liu Pengfei Zhao;Yating Wang;Xiao Yu;Yabing Nan;Shi Liu;Bin Li;Zhumei Cui;Zhihua Liu

作者机构：State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Gynecological OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Obstetrics and GynecologyThe Affiliated Hospital of Qingdao UniversityQingdao266000China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2023年第17卷第5期

页      面：924-938页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key R&D Program of China (No.2021YFC2501000) the CAMS Innovation Fund for Medical Sciences (Nos.2021-I2M-1-018 and 2021-12M-1-067). 

主　　题：0varian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1 

摘      要：Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple cancers.However,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear.In the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors.Gain-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in vitro.Moreover,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis.Mechanistically,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling.Collectively,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker.