Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices

作     者：Kairu Dong Wen-Che Liu Yuyan Su Yidan Lyu Hao Huang Nenggan Zheng John A.Rogers Kewang Nan 

作者机构：College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release SystemsZhejiang UniversityHangzhou 310058China College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou310027China Department of GastroenterologyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China Qiushi Academy for Advanced StudiesZhejiang UniversityHangzhou 310027China College of Computer Science and TechnologyZhejiang UniversityHangzhou 310027China State Key Lab of Brain-Machine IntelligenceZhejiang UniversityHangzhou 310058China CCAI by MOE and Zhejiang Provincial Government(ZJU)Hangzhou 310027China Querrey Simpson Institute for BioelectronicsNorthwestern UniversityEvanstonIL 60208USA Department of Biomedical EngineeringNorthwestern UniversityEvanstonIL 60208USA Department of Materials Science and EngineeringNorthwestern UniversityEvanstonIL 60208USA Department of Mechanical EngineeringNorthwestern UniversityEvanstonIL 60208USA Jinhua Institute of Zhejiang UniversityJinhua 321299China 

出 版 物：《Biomedical Engineering Frontiers》 (生物医学工程前沿（英文）)

年 卷 期：2023年第4卷第1期

页      面：3-20页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：N.Z.acknowledges the support from“STI 2030-Major Projects 2021ZD0200405”and National Natural Science Foundation of China(T2293723 and 61972347) K.N.acknowledges the support from start-up funding for the ZJU100 professorship from Zhejiang University J.A.R.acknowledges funding from the Querrey Simpson Institute for Bioelectronics 

主　　题：offering recording millimeter 

摘      要：Millimeter-scale animals such as Caenorhabditis elegans,Drosophila larvae,zebrafish,and bees serve as powerful model organisms in the fields of neurobiology and *** methods exist for recording large-scale electrophysiological signals from these *** approaches often lack,however,real-time,uninterrupted investigations due to their rigid constructs,geometric constraints,and mechanical mismatch in integration with soft *** recent research establishes the foundations for 3-dimensional flexible bioelectronic interfaces that incorporate microfabricated components and nanoelectronic function with adjustable mechanical properties and multidimensional variability,offering unique capabilities for chronic,stable interrogation and stimulation of millimeter-scale animals and miniature tissue *** review summarizes the most advanced technologies for electrophysiological studies,based on methods of 3-dimensional flexible bioelectronics.A concluding section addresses the challenges of these devices in achieving freestanding,robust,and multifunctional biointerfaces.