Effect of VEGF/GREDVY Modified Surface on Vascular Cells Behavior

作     者：魏来 TAN Jianying LI Li WANG Huanran LIU Sainan ZENG Zheng LIU Tao WANG Jian 陈俊英 WENG Yajun WEI Lai;TAN Jianying;LI Li;WANG Huanran;LIU Sainan;ZENG Zheng;LIU Tao;WANG Jian;CHEN Junying;WENG Yajun

作者机构：School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031 China 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2024年第39卷第1期

页      面：244-254页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Funded by the National Natural Science Foundation of China(Nos.32271377 and 31870955) the National Key Research and Development of China (No.2020YFC1107300-03) 

主　　题：biotin-GREDVY VEGF anticoagulation endothelial cells endothelial progenitor cells 

摘      要：We synthesized B-He/B-GREDVY and immobilized them on avidin-coated *** examine the immobilization of molecules in the material, the following experiments were performed:fluorescein isothiocyanate(FITC) fluorescence staining, water contact angle and atomic force microscopy(AFM) measurements. Besides, the biological evaluation experiments were also performed, such as platelets adhesion and activation, the culturing of smooth muscle cells(SMC) and endothelial cells(EC). These experimental results show that the modified surfaces could prevent the hyperproliferation of SMC, and promote the proliferation and migration of EC and EPC. Furthermore, the adding of VEGF improved the EC adhesion in a dynamic environment. Generally, it is expected that the modified surfaces could be used to accelerate the formation of the newly endothelial layer for the construction of platforms for coronary artery stent therapy.