Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis:a systematic review and Meta-analysis

作     者：ZHOU Mingwang DONG Zhuanli WEI Changhao FENG Lufang WANG Xiaoping LIU Haiping JI Xing YANG Kehu LI Shenghua ZHOU Mingwang;DONG Zhuanli;WEI Changhao;FENG Lufang;WANG Xiaoping;LIU Haiping;JI Xing;YANG Kehu;LI Shenghua

作者机构：Department of OrthopaedicsGansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of Quality ManagementLanzhou Petrochemical General HospitalLanzhou 730050China Department of OrthopaedicsLanzhou Petrochemical General HospitalLanzhou 730050China Evidence-Based Social Science Research CenterSchool of Public HealthLanzhou UniversityLanzhou730000China Evidence-Based Medicine CenterSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu ProvinceLanzhou 730000China Center for Translational MedicineGansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of OrthopaedicsGansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2024年第44卷第2期

页      面：243-250页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Natural Science Foundation-funded Project:Yang Deficiency Constitution of Knee Osteoarthritis and the Wnt/β-catenin Signaling Pathway Regulates the Level of Correlation,and the Constitution Theraphy(No.81260546) Construction Project of Chinese Medicine Inheritance Innovation Platform:Basic and Clinical Application Research on Osteoarthritis of the Knee(Gan Wei Chinese Medicine LetterNo.203) Gansu Provincial Science and Technology Plan Project:Clinical Medical Research Centre for Bone and Joint Degenerative Diseases(18JR2FA009) 

主　　题：osteoarthritis knee randomized controlled trial extracorporeal shockwave therapy hyaluronic acid Meta-analysis 

摘      要：OBJECTIVE:To assess the efficacy and safety of extracorporeal shockwave therapy(ESWT)combined with sodium hyaluronate(HA)for the treatment of knee osteoarthritis(KOA).METHODS:PubM ed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,and SinoMed were searched from inception to July *** quality of the randomized controlled trials was evaluated independently by two reviewers according to the criteria in the Cochrane Collaboration for Systematic *** identified articles were then screened individually using EndnoteX9 for eligibility in this *** heterogeneity among the articles was evaluated using ***:A total of 17 studies,comprising 2000 individuals,were included in this *** results showed that a significant improvement was observed in knee pain and function based on the clinical efficacy of ESWT combined with *** analysis of clinical efficacy showed that[relative risk(RR)=1.21,95%confidence interval(CI)(1.12,1.30),P0.01].Statistical analysis of visual analog scale showed that[standardized mean difference(SMD)=-2.84,95%CI(-4.01,-1.66),P0.01].Western Ontario and McMaster University osteoarthritis index statistical analysis showed that[SMD=-1.57,95%CI(-2.52,-0.61),P0.01].Lysholm score statistical analysis showed that[SMD=1.71,95%CI(0.98,2.44),P0.01].In addition,only minor side effects,such as redness and swelling of the skin,were ***:Medium to low quality evidence showed that ESWT combined with HA offers an inexpensive,welltolerated,safe,and effective method to improve pain and functionality in patients with ***,tightly controlled,randomized,large multicenter trials are warranted to validate the current findings.