DIESL fuels a DGAT-independent triglyceride synthesis pathway

作     者：Lauren F.Uchiyama Peter Tontonoz Lauren F.Uchiyama;Peter Tontonoz

作者机构：Department of Pathology and Laboratory MedicineMolecular Biology InstituteDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095United States 

出 版 物：《Life Metabolism》 (生命代谢（英文）)

年 卷 期：2023年第2卷第6期

页      面：3-5页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：synthesis canonical synthesize 

摘      要：Alternative triglyceride(TG)synthesis pathways have yet to be identified in mammalian *** a recent article published in Nature,Brummelkamp and colleagues reported that the acyltransferase transmembrane protein 68(TMEM68)/DIESL synthesizes TG in the absence of the canonical enzymes dia-cylglycerol acyltransferase 1(DGAT1)and DGAT2.