心脏纤维化机制研究的全新视角

作     者：王海帆 杜晓军 张幼怡 肖晗 Hai-Fan Wang;Xiao-Jun Du;You-Yi Zhang;Han Xiao

作者机构：Department of Cardiology and Institute of Vascular MedicinePeking University Third HospitalBeijing 100191China State Key Laboratory of Vascular Homeostasis and RemodelingPeking UniversityBeijing 100191China NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijing 100191China Beijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Search Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical SciencesBeijing 100191China Institute of Cardiovascular SciencesSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Baker Heart and Diabetes InstituteMelbourne 8008Australia School of Basic Medical SciencesXi’an Jiaotong University Health Science Centerand Cardiometabolic Innovation Center(Ministry of Education)Xi’an 710061China Key Laboratory of Xinjiang Endemic and Ethnic Diseases(Ministry of Education)Shihezi University School of MedicineShihezi 832003China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2023年第68卷第22期

页      面：2704-2708页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Key R&D Program(2021YFF0501401 and 2021YFF0501400) the National Natural Science Foundation of China(82070393) the CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003) the“Tianchi Talent”program the Key Clinical Projects of Peking University Third Hospital(BYSYZD2019022)。 

主　　题：心脏纤维化 pathology cardiac 

摘      要：Cardiac fibrosis is the excessive deposition of extracellular matrix(ECM)proteins in heart tissues leading to functional and electrophysiological abnormalities.Being a common pathology in different diseased conditions,cardiac fibrosis has been regarded as an appropriate(reparative)or inappropriate(reactive)pathological response.