Manganese therapy for dyslipidemia and plaque reversal in murine models

作     者：Yawei Wang Xin Feng Wenjing Zhou Runze Huang Yating Hu Hui Hui Jie Tian Xiao Wang Xiao-Wei Chen Yawei Wang;Xin Feng;Wenjing Zhou;Runze Huang;Yating Hu;Hui Hui;Jie Tian;Xiao Wang;Xiao-Wei Chen

作者机构：State Key Laboratory of Membrane BiologyPeking UniversityBeijing 100871China Institute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijing 100871China PKU-THU Joint Center for Life SciencesPeking UniversityBeijing 100871China CAS Key Laboratory of Molecular ImagingInstitute of AutomationChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Molecular ImagingBeijing 100190China School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100080China 

出 版 物：《Life Metabolism》 (生命代谢（英文）)

年 卷 期：2023年第2卷第6期

页      面：82-87页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The work is supported by the National Natural Science Foundation of China(NSFC:32125021,92254308,91957119,91954001,31571213 to X.W.C,32100947 to X.W.,and 62027901 to J.T.) the National Key R&D Program(2021YFA0804802) 

主　　题：manganese homeostasis initially 

摘      要：Precise control of circulating lipid levels is vital in both health and *** recently uncovered that bulk lipids,transported by lipoproteins,enter the circulation initially via the coat protein complex II(COPII)in a condensation-dependent *** manganese,acting as a signaling messenger,selectively controls COPII condensation to regulate lipid homeostasis in ***,we present evidence for a manganese-based therapy in murine models of hypolipidemia and hyperlipidemia.