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DNA framework signal amplification platform-based highthroughput systemic immune monitoring

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1115-1131页

作者： Ye Chen Xingyu Chen Bowen Zhang Yuxin Zhang Songhang Li Zhiqiang Liu Yang Gao Yuxuan Zhao Lin Yan Yi Li Taoran Tian Yunfeng Lin State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041 SichuanPR China Department of Prosthodontics Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041PR China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041 SichuanPR China Sichuan Provincial Engineering Research Center of Oral Biomaterials Chengdu 610041 SichuanChina

Systemic immune monitoring is a crucial clinical tool for disease early diagnosis,prognosis and treatment planning by quantitative analysis of immune cells.However,conventional immune monitoring using flow cytometry faces huge challenges in large-scale sample testing,especially in mass health screenings,because of time-consuming,technical-sensitive and high-cost features.However,the lack of high-performance detection platforms hinders the development of high-throughput immune monitoring technology.To address this bottleneck,we constructed a generally applicable DNA framework signal amplification platform(DSAP)based on post-systematic evolution of ligands by exponential enrichment and DNA tetrahedral framework-structured probe design to achieve high-sensitive detection for diverse immune cells,including CD4+,CD8+T-lymphocytes,and monocytes(down to 1/100μl).Based on this advanced detection platform,we present a novel high-throughput immune-cell phenotyping system,DSAP,achieving 30-min one-step immune-cell phenotyping without cell washing and subset analysis and showing comparable accuracy with flow cytometry while significantly reducing detection time and cost.As a proof-of-concept,DSAP demonstrates excellent diagnostic accuracy in immunodeficiency staging for 107 HIV patients(AUC>0.97)within 30 min,which can be applied in HIV infection monitoring and screening.Therefore,we initially introduced promising DSAP to achieve high-throughput immune monitoring and open robust routes for point-of-care device development.

关键词： diagnosis monitoring initially

Esophageal inserted subclavian catheter:a rare complication

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World Journal of Emergency Medicine 2024年第3期15卷 243-245页

作者： DilberÜçöz Kocaşaban SertaçGüler Emergency Medicine Clinic Health Sciences University Ankara Training and Research HospitalAnkara 06930Turkey

Central venous catheterization(CVC) is an invasive procedure for administering fluids,nutrients,and drugs;monitoring central venous pressure;performing pulmonary artery catheterization;and placing transvenous pacemakers in intensive care units and all specialties,from anesthesia to emergency medicine,for the treatment of trauma and hemodynamically unstable pediatric and adult patients.[1,2]Complications have been observed in more than 15% of patients who underwent CVC.Mechanical,infectious,and thrombotic complications have been reported in 5%–19%,5%–26%,and 2%–26% of patients,respectively.[3] Malposition,on the other hand,is common in subclavian catheter insertion and is usually associated with an initially misplaced guidewire.[4]

关键词： unstable insertion initially

Shedding light on gene therapy of Parkinson’s disease in non-human primates

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The Innovation 2024年第2期5卷 15-16页

作者： Xunyi Yan Xin Jin New Cornerstone Science Laboratory Center for Motor Control and DiseaseKey Laboratory of Brain Functional GenomicsEast China Normal University3663 North Zhongshan RoadShanghai 200062China NYU–ECNU Institute of Brain and Cognitive Science New York University Shanghai3663 North Zhongshan RoadShanghai 200062China

Parkinson’s disease(PD)is a progressive neurodegeneration disease initially described by James Parkinson.It is typically diagnosed based on clinical features such as bradykinesia,resting tremor,rigidity,and,in later stages,postural instability.Epidemiologically,the prevalence of PD ranges from 5 to over 35 cases per 100,000 population,with the majority affecting individuals aged 50 years or older.The risk increases with age,particularly in males.Various factors,including genetics,lifestyle,specific environmental influences,and geometry,contribute to the disease.

关键词： clinical rigidity initially

Grouping-Based Optimal Design of Collector System Topology for a Large-Scale Offshore Wind Farm by Improved Simulated Annealing

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Protection and Control of Modern Power Systems 2024年第1期9卷 94-111页

作者： Ruilin Chen Zeyu Zhang Junxuan Hu Lei Zhao Chuangzhi Li Xiaoshun Zhang Shantou University ShantouChina ZHONGNAN ENGINEERING CORPORATION LIMITED North China Electric Power University Department of Electronic and Information Engineering College of EngineeringShantouUniversityShantouChina Sichuan university ChengduChina Foshan Graduate School Northeastern UniversityFoshan 528311China College of Information Science and Engineering Northeastern UniversityShenyang 110819China

During the construction of an offshore wind farm(OWF),the capital cost of the collector cable system accounts for a large proportion of the total cost.Consequently,the optimal design of the collector system topology(CST)is one of the most crucial tasks in OWF planning.However,for a large-scale OWF,the optimal design of CST is a complex integer programming problem with high-dimension variables and various constraints.Therefore,it is difficult to acquire a high-quality optimal design scheme.To address this issue,this paper proposes a new grouping-based optimal design of CST for a large-scale OWF.First,all the wind turbines are divided into multiple groups according to their geographical locations and the maximum allowed connected wind turbines by each cable.This not only reduces the optimization dimension and difficulty,but also effectively satisfies the‘no cross’constraint by putting the geographically closed wind turbines into the same group.Secondly,the electrical topology among different wind turbines in each group is initially generated by an improved dynamic minimum spanning tree(DMST).The division groups of the OWF are then adjusted to further reduce the capital cost by improved simulated annealing.To verify the proposed technique,comparison case studies are carried out with five algorithms on two different OWF.

关键词： dimension Optimal initially

Civil Ambassador Enriches Peru-China Relations

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China News Release 2024年第2期 54-57页

作者： Rubén Tang the Pontificia Catholic University of Peruand Asian Academic Institutions

Peru and China are both ancient countries with rich histories and cultures.Chinese immigration to Peru is the most significant in Latin America.The first Chinese immigrants arrived in Peru in 1849 to seek a new future in these distant lands.They initially worked in the fields and later established successful businesses,making important contributions to the country's development across various sectors.

关键词： initially Latin Per

Drone systems for delivering defibrillators for sudden cardiac arrests

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Journal of Acute Disease 2024年第1期13卷 1-2页

作者： Thirumurugan E Edwin Dias Karthick R Srinivas University MangaloreKarnatakaIndia Faculty of Allied Health Science DR MGR Educational and Research InstituteACS Medical CollegeChennaiTamil NaduIndia

Unmanned aerial vehicles(UAVs),or drones,that were initially developed for military use during World War I[1],have evolved into highly sophisticated aircraft that can be navigated remotely using global positioning systems.With constant improvements,drones have become more efficient,and cost-effective,with longer battery life and greater loading capacity.Today,UAVs have proven to be an effective and affordable solution for enhancing healthcare accessibility for patients who face geographical or infrastructural barriers.Using drone networks can greatly reduce the time transporting life-saving equipment,such as delivering automated external defibrillators(AEDs),to cardiac arrest victims,and can provide quick assistance to reduce travel time for the patients.

关键词： initially travel battery

THE GREAT‘OVERCAPACITY’DEBATE

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Beijing Review 2024年第21期67卷 16-17页

作者： Michael Zakkour U.S.-based consulting firms 5 New Digital and China BrightStar

Modern China and its wealthwere initially forged in the country's factories,making virtually every category of consumer and industrial product that the rest of the world wanted and for which global companies sought a ... 详细信息

关键词： companies solution. initially

Collaborating to shape the future of the textile industry

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China Textile 2024年第1期 32-33页

Worst business situation recorded in the survey.The global textile industry has been caught in a perfect storm for a long time,much longer that initially expected.This is true for all regions and all segments due to l... 详细信息

关键词： initially industry storm

Proximal-type epithelioid sarcoma of the vulva initially misdiagnosed as Bartholin cyst: A case report

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Gynecology and Obstetrics Clinical Medicine 2022年第3期2卷 157-159页

作者： Rafael Everton Assunçao Ribeiro da Costa Luis Felipe Rodrigues Brandao de Barros Raimundo Geronimo da Silva Júnior Eugenio de Sa Coutinho Neto Eid Gonçalves Coelho Carlos Eduardo Coelho de Sa Health Science Center State University of PiauíTeresinaPIBrazil Health Science Center Federal University of PiauíTeresinaPIBrazil Oncology High Complexity Assistance Unit Dr.Everardo Aragao Macroregional Hospital in CaxiasCaxiasMABrazil

Dear editor,Vulvar sarcomas are rare and represent 1%–3%of cancers in this region.1 Leiomyosarcoma is the most common type of vulvar sarcoma.In contrast,epithelioid sarcoma(ES)is extremely rare,accounting for around 1%of soft-tissue vulvar sarcomas.Among the ESs of the vulva,proximal variants tend to have a more aggressive clinical course,in comparison to distal variants.2 The treatment of choice in proximal-type ES of the vulva is surgical resection,usually with surgical margins greater than 2 cm.Due to the extreme rarity of these malignancies,clear algorithms for adjuvant treatment of these tumors have still not been established.Radiotherapy and/or chemotherapy may be indicated in some cases.

关键词： sarcoma chemotherapy initially