Small molecular decoys in Alzheimer's disease

作     者：Sho Oasa Valentina L.Kouznetsova Igor F.Tsigelny Lars Terenius Sho Oasa;Valentina L.Kouznetsova;Igor F.Tsigelny;Lars Terenius

作者机构：Department of Clinical NeuroscienceCenter for Molecular MedicineKarolinska InstitutetStockholmSweden San Diego Supercomputer CenterUniversity of California San DiegoLa JollaCAUSA Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA Department of Clinical NeuroscienceKarolinska University HospitalKarolinska InstitutetStockholmSweden 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第8期

页      面：1658-1659页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：supported by several grant agencies as stated in the full paper(to LT) 

主　　题：Alzheimer decoy Aβ 

摘      要：Recent progress in the treatment of Alzheimer’s disease(AD)using antibodies against amyloid sustains amyloid generation as a key process in *** formation starts with two amyloidbeta(Aβ)molecules interacting(dimer formation)followed by an accelerating build-up of socalled protofibrils,which turn into fibrils,which accumulate in the characteristic plaques.