Magnesium alloys in tumor treatment:Current research status, challenges and future prospects

作     者：Yuchien Hsu Yupu Lu Siyi Wang Yufeng Zheng Dandan Xia Yunsong Liu 

作者机构：Department of ProsthodonticsPeking University School and Hospital of StomatologyBeijing100081China National Center for StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100081China Department of Dental MaterialsPeking University School and Hospital of StomatologyBeijing100081China Department of ProsthodonticsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyChina Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2023年第11卷第10期

页      面：3399-3426页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key R&D Program of China [grant number 2021YFC2400700] the National Natural Science Foundation of China [grant numbers 82170929,81970908] the Beijing Natural Science Foundation [L222090,L222030] 

主　　题：Antitumor Cancer Magnesium alloys Mechanism Tissue regeneration 

摘      要：Cancer is a major threat to human life worldwide. Traditional cancer treatments, such as chemotherapy and surgery, have major limitations and can cause irreversible damage to normal tissues while killing the cancer cells. Magnesium(Mg) alloys are widely reported novel potential biomedical materials with acceptable mechanical properties and good osteogenic and angiogenic properties. In this review, we summarize the Mg alloys for antitumor applications, including pure Mg and Mg alloys(Mg-Ag, Mg-Gd, Mg-Li-Zn, Mg-Ca-Sr-Zn, et al.) fabricated by casting and extruding, selective laser melting methods. Mg alloys can exhibit antitumor effect on bone tumor, breast cancer, and liver tumor,etal. What s more, after tumor tissue is eliminated, Mg alloys prevent tumor recurrence, fill tissue defects and promote tissue *** antitumor effects of Mg alloys are mainly due to their degradation products. Overall, Mg alloys show great potential in tumor treatments due to the dual function of antitumor and tissue regeneration.