Identification of methylated differentially expressed hub genes in systemic lupus erythematosus patients by WGCNA-based epigenome-wide and transcriptome-wide analysis

作     者：Qiao Zhou Li Long Xixi Chen Xiaobo Huang Shaoping Deng Yi Wang Qiao Zhou;Li Long;Xixi Chen;Xiaobo Huang;Shaoping Deng;Yi Wang

作者机构：Department of Rheumatology and ImmunologySichuan Academy of Medical Science and Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Clinical Immunology Translational Medicine Key Laboratory of Sichuan ProvinceSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Critical Care MedicineSichuan Academy of Medical Science and Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China 

出 版 物：《Genes & Diseases》 (基因与疾病(英文))

年 卷 期：2023年第10卷第5期

页      面：1771-1774页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81802504,81872207) Sichuan Science and Technology Bureau,China(No.2019YFS0439,2020JDJQ0067,2020JDRC0118,2021YJ0564,and 2022YFH0005) the Science and Technology Innovation Project of Chengdu,China(No.2021-YF05-00225-SN) a Sichuan Medical Association grant(China)(No.Q19037). 

主　　题：lupus erythematosus SLE 

摘      要：Systemic lupus erythematosus(SLE)is an autoimmune disease,characterized by the production of autoantibodies and the involvement of multi-systems.In order to explore its molecular mechanism,we,using bioinformatics analysis and wet lab experiments,identified two key genes in SLE patients.