Exploration of Related Issues on PK/PD Studies and Bioanalytical Characteristics of Peptides
Exploration of Related Issues on PK/PD Studies and Bioanalytical Characteristics of Peptides作者机构：Center for Drug Evaluation National Medical Products Administration Beijing China
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2023年第11卷第11期
页 面：76-93页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Peptides Drugs PK/PD Bioanalytical Characteristics
摘 要：Peptides play multiple functions in cellular processes and are considered an attractive paradigm for the development of novel drugs and therapeutic approaches. However, the complexity of their pharmacokinetics/pharmacodynamics and physicochemical properties presents challenges in their development. Currently, there is no single analytical method that fully meets the requirements for studying peptide drug pharmacokinetics. Interdisciplinary teams and multiple technical platforms are required to address these challenges. This article explores the pharmacokinetics, bioanalytical methods, challenges, and strategies in the development of peptide drugs. As our understanding of peptide drug pharmacokinetics and bioanalytical characteristics deepens, it will facilitate their development and provide scientific evidence for rational clinical use.
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