月经周期中免疫球蛋白G N-糖基化的周期性变化

作     者：Julija Juric Hongli Peng Manshu Song Frano Vuckovic JelenaŠimunovic Irena TrbojevicAkmacic Youxin Wang Jiaonan Liu Qing Gao Hao Wang Qiaoyun Chu Marija Pezer Wei Wang Gordan Lauc Julija Jurić;Hongli Peng;Manshu Song;Frano Vučković;Jelena Šimunović;Irena Trbojević-Akmačić;Youxin Wang;Jiaonan Liu;Qing Gao;Hao Wang;Qiaoyun Chu;Marija Pezer;Wei Wang;Gordan Lauc

作者机构：Genos Glycoscience Research LaboratoryZagreb 10000Croatia Hospital of Traditional Chinese MedicineFengtai DistrictBeijing 100076China Beijing Municipal Key Laboratory of Clinical EpidemiologySchool of Public HealthCapital Medical UniversityBeijing 100069China Centre for Precision HealthEdith Cowan UniversityPerthWA 6027Australia School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Biochemistry and Molecular BiologyFaculty of Pharmacy and Biochemistry at University of ZagrebZagreb 10000Croatia 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2023年第26卷第7期

页      面：108-118,I0005页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：funded by the European Structural and Investment Funds grant for the Croatian National Centre of Research Excellence in Personalized Healthcare(KK.01.1.1.01) Australia-China International Collaborative Grant(NHMRC APP1112767-NSFC 81561128020) National Natural Science Foundation of China(81773527 and 81573215) the European Structural and Investment Funds CEKOM(KK.01.2.2.03.0006) 

主　　题：N-glycosylation Immunoglobulin G Menstrual cycle Female sex hormones Estrogen Progesterone Testosterone Women 

摘      要：Immunoglobulin G(IgG)is the most abundant plasma glycoprotein and a prominent humoral immune *** composition affects the affinity of IgG to ligands and consequent immune *** modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune *** the menstrual cycle is the central sex hormonerelated physiological process in most women of reproductive age,IgG N-glycosylation dynamics during the menstrual cycle have not yet been *** fill this gap,we profiled the plasma IgG Nglycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles(every 7 days for 3 months)using hydrophilic interaction ultra-performance liquid chromatography(HILIC-UPLC).We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in *** the integrated cohort level,the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait,with the highest being 1.1%for agalactosylated ***,intrapersonal changes were relatively high in some cases;for example,the largest difference between the minimum and maximum values during the menstrual cycle was up to 21%for sialylated *** all measurements,the menstrual cycle phase could explain up to 0.72%of the variation in the abundance of a single IgG glycosylation trait of *** contrast,up to 99%of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG *** conclusion,the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small;thus,the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.