Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers

作     者：Godwin Sokpor Huu Phuc Nguyen Tran Tuoc Godwin Sokpor;Huu Phuc Nguyen;Tran Tuoc

作者机构：Department of Human GeneticsRuhr University of BochumBochumGermany Lincoln Medical SchoolUniversity of LincolnLincolnUK 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第11期

页      面：5132-5133页

核心收录：

学科分类：070902[理学-地球化学] 0709[理学-地质学] 07[理学] 

基　　金：supported by the following grants: RUB/FoRUM supported by DFG Schram-Stiftung supported by the Open Access Publication Funds of Ruhr-University Bochum 

主　　题：establishing complexes preserving 

摘      要：A recent study published in Nature reveals an interaction between SWI/SNF subunits and mitotic chromatin,which is essential for establishing gene bookmarks and preserving cell identity.1 The findings deepen our understanding of how SWI/SNF complexes regulate transcriptional memory heritability for cell fate commitment(Fig.1),thus validating the indispensability of SWI/SNF complexes in development and association of their perturbance with tumorigenesis and neurodevelopment disorders.