ELP3 stabilizes c-Myc to promote tumorigenesis
作者机构：State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Department of Neurosurgery and Department of NeuroscienceFujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361003China
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2023年第15卷第9期
页 面：40-52页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：supported by grants from China Postdoctoral Science Foundation(2022M712672) the National Natural Science Foundation of China(U21A20373 and 32070749)
主 题：ELP3 c-Myc FBXW7 Elongator
摘 要：ELP3,the catalytic subunit of the Elongator complex,is an acetyltransferase and associated with tumor ***,the detail of ELP3 oncogenic function remains largely ***,we found that ELP3 stabilizes c-Myc to promote tumorigenesis in an acetyltransferase-independent ***,ELP3 competes with the E3-ligase FBXW7βfor c-Myc binding,resulting in the inhibition of FBXW7β-mediated ubiquitination and proteasomal degradation of ***3 knockdown diminishes glycolysis and glutaminolysis and dramatically retards cell proliferation and xenograft growth by downregulating c-Myc,and such effects are rescued by the reconstitution of c-Myc ***,ELP3 and c-Myc were found overexpressed with a positive correlation in colorectal cancer and hepatocellular *** together,we elucidate a new function of ELP3 in promoting tumorigenesis by stabilizing c-Myc,suggesting that inhibition of ELP3 is a potential strategy for treating c-Myc-driven carcinomas.
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