Liquid–liquid phase separation in synaptopathies

作     者：Huihui Jiang Haitao Wu Huihui Jiang;Haitao Wu

作者机构：Department of NeurobiologyBeijing Institute of Basic Medical SciencesBeijingChina Chinese Institute for Brain ResearchBeijingChina Key Laboratory of NeuroregenerationCo‐innovation Center of NeuroregenerationNantong UniversityNantongJiangsuChina 

出 版 物：《Neuroprotection》 (神经保护（英文）)

年 卷 期：2023年第1卷第1期

页      面：34-45页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：National Key Reserach and Development Program of China,Grant/Award Numbers:2021ZD0202500,2021YFA1101801 National Natural Science Foundation of China,Grant/Award Numbers:32171148,31770929,31522029 Beijing Municipal Science and Technology Commission of China,Grant/Award Numbers:Z181100001518001,Z161100000216154 

主　　题：neurodegenerative disorder neurodevelopmental disorder phase separation synapse synaptopathy 

摘      要：Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane-less *** the nervous system,the formation of distinct molecular condensates via phase separation is involved in synaptic assembly and *** of phase separation is associated with several disease states,such as cancer,neurodegenerative disorders,and neurodevelopmental *** review summarizes the function of phase separation in the assembly and plasticity of the synapse,discusses the role of abnormal phase separation in neurological diseases,and proposes potential treatment options for these neurological diseases based on phase separation.