Multifunctional glycolipids as multi-targeting therapeutics for neural regeneration

作     者：Yutaka Itokazu Yutaka Itokazu

作者机构：Department of Neuroscience and Regenerative MedicineMedical College of GeorgiaAugusta UniversityAugustaGAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第4期

页      面：707-708页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a National Institute of Neurological Disorders and Stroke grant(R01 NS100839) a Sheffield Memorial Grant of the CSRA Parkinson’s Disease Support Group,and the excellent infrastructural support of the Department of Neuroscience and Regenerative Medicine,Medical College of Georgia at Augusta University(all to YI). 

主　　题：lipids involvement diseases 

摘      要：Many patients with neurodegenerative diseases,such as Alzheimer’s(AD)and Parkinson’s(PD)diseases suffer from disease progression without any satisfying clinical intervention,likely due to our lack of knowledge on how normal aging impacts the pathogenic mechanisms of these debilitating diseases.A growing body of literature has emerged in recent years that clearly demonstrates the involvement of glycolipids in the protein-oligomerization of neurodegenerative disorders.We hypothesize that changes in glycolipids composition are a common mechanism underlying the shift from healthy brain aging to the neuropathological processes of neurodegenerative diseases.