Endostatin specifically targets both tumor blood vessels and lymphatic vessels

作     者：Wei Zhuo Yang Chen Xiaomin Song Yongzhang Luo 

作者机构：National Engineering Laboratory for Anti-tumor Protein TherapeuticsBeijing 100084China Beijing Key Laboratory for Protein TherapeuticsBeijing 100084China Cancer Biology LaboratorySchool of Life SciencesTsinghua UniversityBeijing 100084China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2011年第5卷第4期

页      面：336-340页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported in part by the General Programs of the National Natural Science Foundation of China(Grant No.30771083) the National High Technology Research and Development Program of China(No.2007AA02Z155 and No.2008AA02Z136) the National Science and Technology Major Project(No.2009ZX09103-703 and No.2009ZX09306-002)。 

主　　题：endostatin angiogenesis lymphangiogenesis nystatin internalization tumor 

摘      要：Endostatin,a 20 kDa C-terminal fragment of collagen XVIII,was first identified as a potent angiogenic inhibitor.The anti-angiogenic function of endostatin has been well documented during the past decade.Recently,several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic metastasis.However,the exact mechanism that endostatin executes its anti-angiogenic and anti-lymphangiogenic functions remains elusive.In the current mini-review,we briefly summarize recent novel findings,including the functions of endostatin targeting not only angiogenesis but also lymphangiogenesis,and the underlying mechanism by which endostatin internalization regulates its biological functions.