Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage

作     者：Yue Yu Yinuo Zhang Yu Wang Wenxing Chen Zhanjun Guo Ningning Song Minmin Liang Yue Yu;Yinuo Zhang;Yu Wang;Wenxing Chen;Zhanjun Guo;Ningning Song;Minmin Liang

作者机构：Experimental Center of Advanced MaterialsSchool of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Synchrotron Radiation FacilitiesShanghai Institute of Applied PhysicsChinese Academy of ScienceShanghai 201204China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第8期

页      面：10763-10769页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.52202344,T2225026,82172087,and 82071308) the National Key R&D Program of China(No.2022YFA1205801) Beijing Institute of Technology Research Fund Program for Young Scholars. 

主　　题：MnO_(2)@graphene oxide(MnO_(2)@GO)nanozyme superoxide dismutase(SOD)-like activity activity specificity antioxidation 

摘      要：Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)nanozymes.Here,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural Mn-SOD.This MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic reactions.Thus,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,respectively.Additionally,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.