Microbiological cultures and antimicrobial prophylaxis in patients undergoing total pancreatectomy with islet cell autotransplantation

作     者：Kristen R Szempruch Anne M Lachiewicz Brittney M Williams Aman Kumar Xavier Baldwin Chirag S Desai Kristen R Szempruch;Anne M Lachiewicz;Brittney M Williams;Aman Kumar;Xavier Baldwin;Chirag S Desai

作者机构：Pharmacy DepartmentUniversity of North Carolina Medical CenterChapel HillNCUSA Division of Infectious DiseaseUniversity of North Carolina Medical CenterChapel HillNCUSA Department of SurgeryTransplantUniversity of North Carolina Medical CenterChapel HillNCUSA 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2023年第22卷第4期

页      面：426-429页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：islet patients viable 

摘      要：To the Editor:Total pancreatectomy with islet cell autotransplantation(TPIAT)is a viable treatment option upon failed endoscopic and medical therapy for patients with chronic pancreatitis.This procedure involves surgical removal of the entire pancreas,isolation of islet cells and reinfusion of these cells into the liver via portal vein[1,2].The risk of contamination to the final islet cell product can occur at several stages of the isolation procedure[3].In order to ensure the sterility of the islet cell product,multiple samples from the preservation and cannulation solution,and the final islet cell product are sent for bacterial cultures.Prior studies have found variable clinical consequences of these cultures on infectious com-plications or graft function[3-9].Herein we aimed to determine the incidence of infection in 60 days post-TPIAT and its association with the culture data.