Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse(Apodemus agrarius):evidence from both laboratory and field experiments
作者机构：Shaanxi Key Laboratory for Animal ConservationShaanxi Institute of ZoologyXi’anChina College of Life SciencesShaanxi Normal UniversityXi’anChina
出 版 物：《Integrative Zoology》 (整合动物学（英文版）)
年 卷 期：2022年第17卷第6期
页 面：1041-1052页
核心收录：
学科分类：0710[理学-生物学] 0905[农学-畜牧学] 09[农学] 0906[农学-兽医学] 0904[农学-植物保护]
基 金：supported by the Science and Technology Program of Shaanxi Academy of Sciences(2017K-11,2018k-04,2020k-21) the international Partnership of Chinese Academy of Sciences(Grant No.152111KYSB20160089) the Key Research and Development Program of Shaanxi(2018NY-135,2021NY-042) the Science and Technology Innovation Program of Shaanxi Academy of Forestry(SXLK2020-0209) the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,2019QZKK0501).
主 题：Apodemus agrarius fertility control levonorgestrel quinestrol
摘 要：The effect of combined levonorgestrel(P)and quinestrol(E)on the fertility of stripedfield mouse(Apodemus agrarius)has not been evaluated.We performed a series of experiments in both the laboratory andfield to assess the effect of P and/or E on the fertility of A.agrarius.In the laboratory,to test the time-dependent anti-fertility ef-fects of P and E,as well as their mixtures,90 male stripedfield mice were randomly assigned to 6 treatment groups(n=60),and a control group(n=30).Mice in 3 treatment groups were administered 1 of the 3 compounds(1 mg�kg–1[body weight]EP-1,0.34 mg�kg–1 E,0.66 mg�kg–1 P)for 3 successive days(another half for 7 suc-cessive days)via oral gavage;mice were then sacrificed 15 and 45 days after initiating the gavage treatment.Ourfindings indicated that E and EP-1 treatment,but not P or control treatment,significantly decreased the sperm count in the caudal epididymis,as well as the weight of the testes,epididymides,and seminal vesicles.Additionally,fer-tile female mice mated with E-and EP-1-treated males produced smaller pups.These data indicate that E and EP-1 can induce infertility in male A.agrarius.In thefield,the population density of A.agrarius was significantly influ-enced by EP-1,and the rodent density in the treatment group was lower than that in the control group.Overall,our results indicate that EP-1 is an effective contraceptive in A.agrarius,a dominant rodent species in the farmland.
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