Exploring the anti-cancer effect of taraxasterol using network pharmacology, molecular docking and in vitro experimental validation
作者机构：Hubei Key Laboratory of Renal Disease Occurrence and InterventionSchool of MedicineHubei Polytechnic UniversityHuangshi 435003China Department of DermatologyHuangshi Central HospitalHuangshi 435000China Department of PediatricsHuangshi Maternal and Child Health Care HospitalHuangshi 435003China
出 版 物：《TMR Pharmacology Research》 (TMR药理学研究)
年 卷 期：2023年第3卷第2期
页 面：1-15页
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：This study was supported by local special projects in major health of Hubei Provincial Science and Technology Department(2022BCE054) key scientific research projects of Hubei polytechnic University(23xjz08A)
主 题：anti-cancer molecular docking network pharmacology taraxasterol
摘 要：Taraxasterol(TS)is a naturally occurring pentacyclic triterpenoid extracted from the traditional Chinese herb Taraxacum *** studies have highlighted its significant roles in exhibiting anti-inflammatory,anti-oxidant,and liver protective *** the present study,the anti-cancer potential of TS against cervical cancer was investigated,employing network pharmacology techniques,molecular docking,and in vitro experimental *** exhibits its anticancer properties by modulating multiple targets,pathways,and biological *** vitro experiments demonstrated the potent inhibitory effects of TS on cancer cell growth and migration,while no significant impact on apoptosis was *** primary objective was to elucidate the anti-cancer potential of TS,which is a crucial lead compound in the treatment of cervical *** findings may serve as a basis for the development of novel anticancer therapeutics and medicine-based interventions for cervical cancer.
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