体外人源三维肠道器官模型在微生物通讯中的研究进展

作     者：王慧 尤晓颜 赵国屏 Hui Wang;Xiao-Yan You;Guo-Ping Zhao

作者机构：Master Lab for Innovative Application of Nature ProductsNational Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin 300308China Henan Engineering Research Center of Food MicrobiologyCollege of Food and BioengineeringHenan University of Science and TechnologyLuoyang 471023China CAS-Key Laboratory of Synthetic BiologyCAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Engineering Laboratory for NutritionShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Quantitative Engineering BiologyShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2023年第68卷第13期

页      面：1353-1358页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC042) the National Natural Science Foundation of China(31200035) the China Postdoctoral Science Foundation(2022M713330) 

主　　题：metabolism difficulty ecosystem 

摘      要：The human gut is inhabited by numerous and diverse microbial communities,forming a complex and dynamic ecosystem that regulates digestion,absorption,metabolism,and ***,host-microbe interactions are complex and not well understood due to the difficulty of accessing some sections of the intestinal tract in *** divergence in interspecies and intestinal microbial composition between animal models and humans as well as the difficulty in inferring causation from metagenomic sequencing have promoted the development of the human-relevant in vitro ecosystem of the gut-microbiota communication.