Lighting up Oxytocin Neurons to Nurture the Brain

作     者：Fang Zhou Junqiang Zheng Han Xu 

作者机构：Department of Neurobiology and Department of Neurology of the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Liangzhu LaboratoryMOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-machine IntelligenceZhejiang UniversityHangzhou 311121China NHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang UniversityHangzhou 310058China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第5期

页      面：866-868页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：supported by grants from the National Natural Science Foundation of China(32125018 and 32071005) the Fundamental Research Funds for the Central Universities,the MOE Frontiers Science Center for Brain Science&Brain-Machine Integration of Zhejiang University,and Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20211102). 

主　　题：neonatal neural sensory 

摘      要：The sensory system develops earlier than the systems responsible for higher brain functions such as language and cognition[1].Moreover,sensory experiences in early life are critical for the development of the brain.However,how sensory experiences shape brain development is an important yet unresolved question in neuroscience.Previous work has demonstrated that deprivation of sensory inputs in the early developmental stage causes synaptic dysfunction in the sensory cortex.Interestingly,it has been reported that oxytocin can restore the deficits caused by somatosensory deprivation in neonatal mice,suggesting that oxytocin may play a key role in sensory-mediated synaptogenesis[2].Vision is one of the most important sensory inputs during early development in mammalians including humans[1],but the neural mechanism underlying vision-mediated brain development is still largely unknown.