幽门腺化生可能通过CDX2表达引起肠上皮化生甚至直接进展为胃癌

作     者：Kazuyoshi Yagi Atsunori Tsuchiya Satoru Hashimoto Taisuke Kato Osamu Onodera Shuji Terai 

作者机构：Department of Gastroenterology and HepatologyUonuma Institute of Community MedicineNiigata University Medical and Dental HospitalNiigataJapan Division of Gastroenterology and HepatologyGraduate School of Medical and Dental SciencesNiigata UniversityNiigataJapan Department of System Pathology for Neurological DisordersBrain Science BranchBrain Research InstituteNiigata UniversityNiigataJapan Department of NeurologyBrain Research InstituteNiigata UniversityNiigataJapan 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2021年第9卷第4期

页      面：370-373,I0003页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a Grant-in-Aid for Scientific Research(C)[19K08389]from the Ministry of Education Culture Sports Science and Technology of Japan. 

主　　题：肠上皮化生 幽门腺 Helicobacter CDX2 

摘      要：Introduction The majority of cases of gastric cancer are thought to develop due to chronic inflammation from Helicobacter pylori(H.pylori)infection leading to intestinal metaplasia,termed the intestinal metaplasia–dysplasia–cancer sequence[1].Chronic inflammation from H.pylori infection causes mucin core protein 6-positive(MUC6t)pyloric-gland metaplasia;however,its origin is controversial.This MUC6t pyloric-gland metaplasia is similar to spasmolytic polypeptide-expressing metaplasia in mouse studies[2–4].