Splicing factor PRP-19 regulates mitochondrial stress response

作     者：Peixue Xia Liankui Zhou Jialiang Guan Wanqiu Ding Ying Liu 

作者机构：State Key Laboratory of Membrane BiologyInstitute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China PKU-Tsinghua-NIBS Graduate ProgramAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for GenomicsBeijingChina 

出 版 物：《Life Metabolism》 (生命（代谢（英文）)

年 卷 期：2022年第1卷第1期

页      面：81-93页

学科分类：081702[工学-化学工艺] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 0703[理学-化学] 

基　　金：Y.L.was supported by grants from the National Natural Science Foundation of China(31925012 and 91854205) an HHMI International Research Scholar Program(55008739) This work was also supported by the Beijing Advanced Innovation Center for Genomics and the Peking-Tsinghua Center for Life Sciences 

主　　题：mitochondria unfolded protein response stress response splicing lifespan 

摘      要：Animals respond to mitochondrial perturbation by activating the mitochondrial unfolded protein response(UPR^(mt))to induce the transcription of mitochondrial stress response *** Caenorhabditis elegans,activation of UPR^(mt) allows the animals to maintain organismal homeostasis,activate the innate immune response,and promote lifespan ***,we show that splicing factors such as Precursor RNA processing 19(PRP-19)are required for the induction of UPR^(mt) in ***-19 also modulates mitochondrial perturbation-induced innate immune response and lifespan *** of PRP-19 in mammalian cells suppresses UPR^(mt) activation and disrupts the mitochondrial *** findings reveal an evolutionarily conserved mechanism that maintains mitochondrial homeostasis and controls innate immunity and lifespan through splicing factors.