Chemoprevention of neuroblastoma: progress and promise beyond uncertainties
作者机构：Department of Radiation OncologyUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA Stephenson Cancer CenterOklahoma CityOK 73104USA Department of Pathology and Laboratory MedicineUniversity of Texas Health Sciences Center at San AntonioSan AntonioTX 78229USA
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2023年第9卷第1期
页 面：307-327页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Oklahoma Tobacco Settlement Endowment Trust, (R23-02) University of Oklahoma Stephenson Cancer Center National Cancer Institute, NCI, (P30CA225520) National Cancer Institute, NCI Stephenson Cancer Center, SCC
主 题：Neuroblastoma chemoprevention secondary and tertiary chemopreventive phytochemicals retinoids polyphenols terpenes DFMO apoptosis
摘 要：Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer *** current clinical therapy for this deadly disease is multimodal,involving an induction phase with alternating regimens of high-dose chemotherapeutic drugs and load reduction surgery;a consolidation phase with more intensive chemotherapy,radiotherapy,and stem cell transplant;and a maintenance phase with immunotherapy and immune-activating cytokine *** such intensive treatment,children with neuroblastoma have unacceptable life quality and survival,warranting preventive measures to regulate the cellular functions that orchestrate tumor progression,therapy resistance,metastasis,and tumor relapse/***,active efforts are underway to identify novel chemopreventive agents,define their mechanism(s)of action,and assess their clinical *** chemoprevention strategies(e.g.,retinoids,difluoromethylornithine)have already been adopted clinically as part of maintenance phase *** agents are in the pipeline,while many others are in preclinical *** we review the classes of chemopreventive agents investigated for neuroblastoma,including cellular events targeted,mode(s)of action,and the level of *** review:(i)highlights the pressing need for new and improved chemopreventive strategies for progressive neuroblastoma;(ii)lists the emerging classes of chemopreventive agents for neuroblastoma;and(iii)recognizes the relevance of targeting dynamically evolving hallmark functions of tumor evolution(e.g.,survival,differentiation,lineage transformation).With recent gains in the understanding of tumor evolution processes and preclinical and clinical efforts,it is our strong opinion that effective chemopreventive strategies for aggressive neuroblastoma are a near reality.
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