Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts

作     者：Baosheng Wu Xueli Gao Mingling Hu Jing Hu Tianming Lan Tingfeng Xue Wenjie Xu Chenglong Zhu Yuan Yuan Jiangmin Zheng Tao Qin Peidong Xin Ye Li Li Gong Chenguang Feng Shunping He Huan Liu Haimeng Li Qing Wang Zhenhua Ma Qiang Qiu Kun Wang 

作者机构：School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi’an 710072China South China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhou 510300China State Key Laboratory of Agricultural GenomicsBGI-ShenzhenShenzhen 518083China BGI Life Science Joint Research CenterNortheast Forestry UniversityHarbin 150006China National Engineering Laboratory of Marine Germplasm Resources Exploration and UtilizationMarine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China Institute of Deep-Sea Science and EngineeringChinese Academy of SciencesSanya 572000China The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of SciencesInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China College of Life SciencesUniversity of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第11期

页      面：2629-2645页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the National Natural Science Foundation of China(32122021) the National Key Research and Development Program of China(2022YFC3400300) the 1000 Talent Project of Shaanxi Province to Q.Q.and K.W.,the Fundamental Research Funds of Northwestern Polytechnic University the Open Foundation from Marine Sciences in the First-Class Subjects of Zhejiang(OFMS011) 

主　　题：endothermy tuna convergent evolution divergent strategies heat producing tissues 

摘      要：Although most fishes are ectothermic,some,including tuna and billfish,achieve endothermy through specialized heat producing tissues that are modified *** these heat producing tissues evolved,and whether they share convergent molecular mechanisms,remain ***,we generated a high-quality genome from the mackerel tuna(Euthynnus affinis)and investigated the heat producing tissues of this fish by single-nucleus and bulk RNA *** with other teleosts,tuna-specific genetic variation is strongly associated with muscle ***-nucleus RNA-seq revealed a high proportion of specific slow skeletal muscle cell subtypes in the heat producing tissues of *** genes of this cell subtype are associated with the relative sliding of actin and myosin,suggesting that tuna endothermy is mainly based on shivering *** contrast,cross-species transcriptome analysis indicated that endothermy in billfish relies mainly on nonshivering ***,the heat producing tissues of the different species do share some tissue-specific genes,including vascular-related and mitochondrial ***,although tunas and billfishes differ in their thermogenic strategies,they share similar expression patterns in some respects,highlighting the complexity of convergent evolution.