Serum level changes of inflammatory cytokines in patients with moderate to severe acne vulgaris treated with dual-wavelength laser

作     者：Yang Liu Qilin Sun Hui Xu Gang Ma Pinru Wu Yang Liu;Qilin Sun;Hui Xu;Gang Ma;Pinru Wu

作者机构：Department of DermatologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Laser and Aesthetic MedicineShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Plastic and Reconstructive SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China 

出 版 物：《Chinese Journal Of Plastic and Reconstructive Surgery》 (中国整形与重建外科（英文）)

年 卷 期：2023年第5卷第2期

页      面：47-52页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Interdisciplinary Program of Shanghai Jiao Tong University(grant nos.YG2019QNB10 and YG2021QN67) Shanghai Municipal Key Clinical Specialty(grant no.shslczdzk00901) Shanghai Municipal Commission of Health and Family Planning(grant no.202240150) 

主　　题：Acne vulgaris Dual-wavelength laser Inflammatory cytokines Serum 

摘      要：Background:Acne vulgaris(AV)is a common inflammatory skin *** various mechanisms have been indicated in the etiopathogenesis of AV,the exact pathophysiology remains *** lasers have been used to treat AV;however,the serum level changes of inflammatory cytokines after laser therapy have not been *** aimed to investigate the relationship between inflammatory changes and remission on the opposite side in patients with moderate to severe AV after treating half of the face with 595-and 1064-nm dualwavelength ***:In total,18 patients(9 male and 9 female)between 16 and 35 years of age with moderate to severe AV were evaluated in the *** severity was classified according to the Pillsbury grading system of *** were randomized to receive a series of two treatment sessions at intervals of 2 weeks and followed up at 2 weeks after the final treatment.A 3 mL blood sample was drawn from every subject each time,and serum levels of inflammatory cytokines such as interleukin(IL)-6,IL-8,and IL-22 were determined using enzyme-linked immunosorbent assay at baseline and 2 weeks after each *** was determined by a blinded assessment of photographs taken before and after the final ***:Inflammation was significantly reduced on both the treated and untreated sides,and symptoms of AV lesions were *** patients showed a significant increase in serum IL-22 levels after the first laser therapy,with no significant difference in serum IL-6 and IL-8 *** the second laser therapy,serum IL-6,IL-8,and IL-22 levels were significantly *** significant side effects such as bruising,edema,hyperpigmentation,hypopigmentation,or scarring were ***:Half-face treatment with 595-and 1064-nm dual-wavelength laser for moderate and severe AV showed a significant effect of full-face remission,which was associated with a gradual decrease in IL-6,IL-8,and IL-22 levels after half-fac