Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau

作     者：Xingguang ZHANG Wei XU Weilong ZHONG Wencheng ZHANG Cheng YANG Lisa DUAN Haiyan NIU Yanmei DONG Taotao LIU Shihai XIA Bangmao WANG Xingguang ZHANG;Wei XU;Weilong ZHONG;Wencheng ZHANG;Cheng YANG;Lisa DUAN;Haiyan NIU;Yanmei DONG;Taotao LIU;Shihai XIA;Bangmao WANG

作者机构：Department of Gastroenterology and HepatologyTianjin Medical University General HospitalTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjin300052China Department of GastroenterologyCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjin Key Laboratory of Hepatopancreatic Fiberosis and Molecular Diagnosis&TreatmentTianjin300162China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2023年第24卷第9期

页      面：823-838页

核心收录：

学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学] 

基　　金：supported by the Research and Innovation Team Topics of Characteristic Medical Center of Chinese People’s Armed Police Force(No.KYCXTD0503) the National Natural Science Foundation of China(No.82170558) 

主　　题：Gut microbiome Plateau environment Irritable bowel syndrome 

摘      要：The gut microbiome shows changes under a plateau environment,while the disbalance of intestinal microbiota plays an important role in the pathogenesis of irritable bowel syndrome(IBS);however,the relationship between the two remains *** this work,we followed up a healthy cohort for up to a year before and after living in a plateau environment and performed 16S ribosomal RNA(rRNA)sequencing analysis of their fecal *** evaluating the participants’clinical symptoms,combined with an IBS questionnaire,we screened the IBS sub-population in our *** sequencing results showed that a high-altitude environment could lead to changes in the diversity and composition of gut *** addition,we found that the longer the time volunteers spent in the plateau environment,the more similar their gut microbiota composition and abundance became compared to those before entering the plateau,and IBS symptoms were significantly ***,we speculated that the plateau may be a special environment that induces *** taxonomic units g_Alistipes,g_Oscillospira,and s_Ruminococcus_torques,which had been proved to play important roles in IBS pathogenesis,were also abundant in the IBS cohort at high ***,the disbalance of gut microbiota induced by the plateau environment contributed to the high frequency of IBS and the psychosocial abnormalities associated with *** results prompt further research to elucidate the relevant mechanism.