Effects of copper-aspirin complex on platelet-neutrophil interactions
Effects of copper-aspirin complex on platelet-neutrophil interactions作者机构：昆明医学院 云南省天然药物药理重点实验室 Kunming 650031 Kunming Shenghuo Pharmaceutical Ltd Co Kunming 650217 Kunming Institute of Precious Metals Kunming 650221
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2004年第25卷第5期
页 面：34-38页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Project supported by the Natural Science Foundation of YunnanProvince No 98C066M.2
主 题：copper aspirin thrombosis platelets neutrophils adhesion platelet aggregation
摘 要：AIM: To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between plateletsand neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawleyrats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregationstimulated by activated neutrophils were observed by rosette assay and Borns method, respectively. RESULTS:Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) dose-dependently prolonged the occlusion time; it signifi-cantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % ofinhibitory concentration (IC50) was (54.64.3) mol/L. Copper-aspirin complex markedly inhibited rat plateletaggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil *** values of IC50 were (224.516.2) mol/L and (820.521.4) mol/L, whereas aspirin had no ***: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property fromaspirin and resulted in a more potent antithrombotic activity.
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