De Novo Design and Synthesis of Polypeptide Immunomodulators for Resetting Macrophage Polarization
作者机构：School of Physical Science and TechnologyShanghaiTech University393 Middle Huaxia RoadShanghai 201210China. ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China. College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang 310027China. Zhejiang LabHangzhouZhejiang 311121China. School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China. Shanghai Clinical Research and Trial CenterShanghai 201210China.
出 版 物：《BioDesign Research》 (生物设计研究（英文）)
年 卷 期：2023年第5卷第1期
页 面：37-48页
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：the National Natural Science Foundation of China(nos.32071347,51973116,21935002,and 52003156) ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University(02020200-K02013008) the China Postdoctoral Science Foundation(2020M681344) joint laboratory grant from Jiangsu Wuzhong Aesthetics Biotech Co.Ltd and the starting grant of ShanghaiTech University.Materials were tested at Analytical Instrumentation Center(#SPST-AIC10112914)and the Center for High-Resolution Electron Microscopy(CћEM),SPST,ShanghaiTech University
主 题：modulator Polarization precise
摘 要：Modulating the extracellular matrix microenvironment is critical for achieving the desired macrophage phenotype in immune investigations or tumor *** de novo protein design and biosynthesis techniques,herein,we designed a biomimetic polypeptide self-assembled nano-immunomodulator to trigger the activation of a specific macrophage *** was intended to be made up of(GGSGGPGGGPASAAANSASRATSNSP)n,the RGD motif from collagen,and the IKVAV motif from *** combination of these domains allows the biomimetic polypeptide to assemble into extracellular matrix-like nanofibrils,creating an extracellular matrix-like milieu for ***,changing the concentration further provides a facile route to fine-tune macrophage polarization,which enhances antitumor immune responses by precisely resetting tumor-associated macrophage immune responses into an M1-like phenotype,which is generally considered to be tumor-killing macrophages,primarily antitumor,and *** metal or synthetic polymer-based nanoparticles,this polypeptide-based nanomaterial exhibits excellent biocompatibility,high efficacy,and precise tunability in immunomodulatory *** encouraging findings motivate us to continue our research into cancer immunotherapy applications in the future.
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